PUBLICATION

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Authors
Aramillo Irizar, P., Schäuble, S., Esser, D., Groth, M., Frahm, C., Priebe, S., Baumgart, M., Hartmann, N., Marthandan, S., Menzel, U., Müller, J., Schmidt, S., Ast, V., Caliebe, A., König, R., Krawczak, M., Ristow, M., Schuster, S., Cellerino, A., Diekmann, S., Englert, C., Hemmerich, P., Sühnel, J., Guthke, R., Witte, O.W., Platzer, M., Ruppin, E., Kaleta, C.
ID
ZDB-PUB-180308-1
Date
2018
Source
Nature communications   9: 327 (Journal)
Registered Authors
Cellerino, Alessandro, Englert, Christoph
Keywords
none
Datasets
GEO:GSE74244
MeSH Terms
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/genetics*
  • Aging/metabolism
  • Aging/pathology
  • Animals
  • Brain/growth & development
  • Brain/metabolism
  • Cardiovascular Diseases/blood
  • Cardiovascular Diseases/genetics*
  • Cardiovascular Diseases/pathology
  • Child
  • Child, Preschool
  • Chronic Disease
  • Diabetes Mellitus/blood
  • Diabetes Mellitus/genetics*
  • Diabetes Mellitus/pathology
  • Fundulidae/genetics
  • Fundulidae/growth & development
  • Fundulidae/metabolism
  • Gene Ontology
  • Genome, Human
  • Humans
  • Infant
  • Liver/growth & development
  • Liver/metabolism
  • Mice
  • Middle Aged
  • Molecular Sequence Annotation
  • Neoplasms/genetics*
  • Neoplasms/metabolism
  • Neoplasms/pathology
  • Neurodegenerative Diseases/blood
  • Neurodegenerative Diseases/genetics*
  • Neurodegenerative Diseases/pathology
  • Skin/growth & development
  • Skin/metabolism
  • Transcriptome*
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Zebrafish/metabolism
PubMed
29382830 Full text @ Nat. Commun.
Abstract
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories similar to the transcriptional alterations observed in degenerative ageing diseases but are in opposite direction to the transcriptomic alterations observed in cancer. We confirm the existence of a similar antagonism on the genomic level, where a majority of shared risk alleles which increase the risk of cancer decrease the risk of chronic degenerative disorders and vice versa. These results reveal a fundamental trade-off between cancer and degenerative ageing diseases that sheds light on the pronounced shift in their epidemiology during ageing.
Errata / Notes
This article is corrected by ZDB-PUB-220906-151 .
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping