Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - the role of Hsp90
- Pfeiffer, J., Tarbashevich, K., Bandemer, J., Palm, T., Raz, E.
- Developmental Biology 436(2): 84-93 (Journal)
- Registered Authors
- Bandemer, Jan, Pfeiffer, Jana, Raz, Erez, Tarbashevich, Katsiyarina
- Hsp90, cancer, cell cycle, in vivo, migration, motility, stress response, zebrafish
- MeSH Terms
- Cell Cycle/genetics*
- Cell Division/genetics*
- Cell Division/physiology
- Cell Movement/genetics*
- Cell Movement/physiology
- Germ Cells/cytology
- Germ Cells/metabolism*
- Germ Cells/physiology
- HSP90 Heat-Shock Proteins/metabolism*
- In Situ Hybridization
- 29477339 Full text @ Dev. Biol.
Pfeiffer, J., Tarbashevich, K., Bandemer, J., Palm, T., Raz, E. (2018) Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - the role of Hsp90. Developmental Biology. 436(2):84-93.
Zebrafish primordial germ cells (PGCs) constitute a useful in vivo model to study cell migration and to elucidate the role of specific proteins in this process. Here we report on the role of the heat shock protein Hsp90aa1.2, a protein whose RNA level is elevated in the PGCs during their migration. Reducing Hsp90aa1.2 activity slows down the progression through the cell cycle, and leads to defects in the control over the MTOC number in the migrating cells. These defects result in a slower migration rate and compromise the arrival of PGCs at their target, the region where the gonad develops. Our results emphasize the importance of ensuring rapid progression through the cell cycle during single-cell migration and highlight the role of heat shock proteins in the process.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes