PUBLICATION
Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
- Authors
- Grigura, V., Barbier, M., Zarov, A.P., Kaufman, C.K.
- ID
- ZDB-PUB-180125-1
- Date
- 2018
- Source
- Biology Open 7(1): (Journal)
- Registered Authors
- Keywords
- Caloric restriction, Cancer models, Melanoma, Metabolism, Obesity
- MeSH Terms
- none
- PubMed
- 29362277 Full text @ Biol. Open
Citation
Grigura, V., Barbier, M., Zarov, A.P., Kaufman, C.K. (2018) Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model. Biology Open. 7(1).
Abstract
The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to 'tune' the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping