ZFIN ID: ZDB-PUB-180124-2 |
Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw
Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G.
Date: | 2018 |
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Source: | Developmental Cell 44(3): 337-347.e5 (Journal) |
Registered Authors: | Barske, Lindsey, Crump, Gage DeKoeyer |
Keywords: | COUP-TF, Endothelin1, Nr2f1, Nr2f2, Nr2f5, bone, cartilage, jaw, nuclear receptor, pharyngeal arches |
Microarrays: | GEO:GSE101719 |
MeSH Terms: |
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PubMed: | 29358039 Full text @ Dev. Cell |
Citation
Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G. (2018) Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Developmental Cell. 44(3):337-347.e5.
ABSTRACT
The jaw is central to the extensive variety of feeding and predatory behaviors across vertebrates. The bones of the lower but not upper jaw form around an early-developing cartilage template. Whereas Endothelin1 patterns the lower jaw, the factors that specify upper-jaw morphology remain elusive. Here, we identify Nuclear Receptor 2f genes (Nr2fs) as enriched in and required for upper-jaw formation in zebrafish. Combinatorial loss of Nr2fs transforms maxillary components of the upper jaw into lower-jaw-like structures. Conversely, nr2f5 misexpression disrupts lower-jaw development. Genome-wide analyses reveal that Nr2fs repress mandibular gene expression and early chondrogenesis in maxillary precursors. Rescue of lower-jaw defects in endothelin1 mutants by reducing Nr2f dosage further demonstrates that Nr2f expression must be suppressed for normal lower-jaw development. We propose that Nr2fs shape the upper jaw by protecting maxillary progenitors from early chondrogenesis, thus preserving cells for later osteogenesis.
ADDITIONAL INFORMATION
- Genes / Markers (27)
- TALEN (3)
- Antibodies (2)
- Engineered Foreign Genes (5)
- Expression and Phenotype Data
- Mutations and Transgenics (16)
- Fish (18)