PUBLICATION
Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model
- Authors
- Yang, Y., Zheng, K., Mei, W., Wang, Y., Yu, C., Yu, B., Deng, S., Hu, J.
- ID
- ZDB-PUB-180118-6
- Date
- 2018
- Source
- Biochemical and Biophysical Research Communications 496(2): 763-769 (Journal)
- Registered Authors
- Keywords
- Anti-inflammatory, Bergapten, Inflammation-resolution, Zebrafish
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/chemistry
- Anti-Inflammatory Agents/pharmacology*
- Disease Models, Animal
- Female
- Ficus/chemistry
- Inflammation/drug therapy*
- Inflammation/immunology
- Macrophages/drug effects*
- Macrophages/immunology
- Male
- Methoxsalen/analogs & derivatives*
- Methoxsalen/chemistry
- Methoxsalen/pharmacology
- Neutrophils/drug effects*
- Neutrophils/immunology
- Nitric Oxide/antagonists & inhibitors
- Nitric Oxide/immunology
- Plant Roots/chemistry
- Reactive Oxygen Species/antagonists & inhibitors
- Reactive Oxygen Species/immunology
- Wound Healing/drug effects*
- Zebrafish/immunology
- PubMed
- 29337062 Full text @ Biochem. Biophys. Res. Commun.
Citation
Yang, Y., Zheng, K., Mei, W., Wang, Y., Yu, C., Yu, B., Deng, S., Hu, J. (2018) Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model. Biochemical and Biophysical Research Communications. 496(2):763-769.
Abstract
Bergapten (5-methoxypsoralen), a coumarin-derivate compound isolated from Ficus hirta roots, was evaluated for its anti-inflammatory and proresolution activities in a tail-cutting-induced zebrafish larvae model. Bergapten was evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(corola: eGFP)" to visualize the effects of the recruitment and clearance of neutrophils and macrophages at the injury site. We found that bergapten significantly suppressed the recruitment of neutrophils and macrophages toward the injury site, as well as promoted the clearance of neutrophils and macrophages from the wound site. We also investigated the reactive oxygen species (ROS) and nitric oxide (NO) level of bergapten in a tail-cutting-induced inflammation zebrafish model. The Results revealed that bergapten effectively inhibited the tail-cutting-induced production of ROS and NO in zebrafish larvae. This study reported for the first time the potential anti-inflammatory and proresolution activities of bergapten in an in vivo zebrafish model, suggesting that bergapten may be a potential candidate for inflammation therapy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping