PUBLICATION
Impact of co-exposure of aldrin and titanium dioxide nanoparticles at biochemical and molecular levels in Zebrafish
- Authors
- Jhamtani, R.C., Shukla, S., Sivaperumal, P., Dahiya, M.S., Agarwal, R.
- ID
- ZDB-PUB-180115-3
- Date
- 2017
- Source
- Environmental Toxicology and Pharmacology 58: 141-155 (Journal)
- Registered Authors
- Keywords
- Aldrin, Bioaccumulation, Environmental toxicology, Oxidative stress, Titanium dioxide nanoparticles, Zebrafish
- MeSH Terms
-
- Aldrin/toxicity*
- Animals
- Brain/drug effects
- Brain/metabolism
- Catalase/metabolism
- Drug Interactions
- Gene Expression/drug effects
- Glutathione/metabolism
- Glutathione Peroxidase/metabolism
- Insecticides/toxicity*
- Kidney/drug effects
- Kidney/metabolism
- Lipid Peroxidation/drug effects
- Liver/drug effects
- Liver/metabolism
- Malondialdehyde/metabolism
- Nanoparticles/toxicity*
- Superoxide Dismutase/genetics
- Superoxide Dismutase/metabolism
- Titanium/toxicity*
- Water Pollutants, Chemical/toxicity*
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 29331773 Full text @ Environ. Toxicol. Pharmacol.
Citation
Jhamtani, R.C., Shukla, S., Sivaperumal, P., Dahiya, M.S., Agarwal, R. (2017) Impact of co-exposure of aldrin and titanium dioxide nanoparticles at biochemical and molecular levels in Zebrafish. Environmental Toxicology and Pharmacology. 58:141-155.
Abstract
Aldrin (ALD), a persistent-organic-pollutant (POP), an organochlorine-cyclodiene-pesticide is highly toxic in nature. Titanium dioxide nanoparticles (TNP) are widely used for various industrial applications. Despite the remarkable research on pesticide toxicity, the work with impact of nanoparticles on POP has been dealt with marginally. Chemicals co-exist in the environment and exhibit interactive effects. An investigation was carried out to evaluate the individual and combined effects of ALD (6 ppm) and TNP (60 ppm) exposure at sub-lethal concentration for 24 h in zebrafish. Significant reversal of lipid peroxidation level in liver and brain tissues and restoration in enhanced catalase activity in all examined tissues were observed in combined group. For other parameters, combined exposure of ALD and TNP does not show significant reversal action on ALD toxicity. Further studies are inline to understand combined effects of both to achieve significant reversal of ALD toxicity by TNP nanoparticles with threshold concentration of aldrin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping