PUBLICATION
Gene locations may contribute to predicting gene regulatory relationships
- Authors
- Meng, J., Xu, W.Y., Chen, X., Lin, T., Deng, X.Y.
- ID
- ZDB-PUB-180109-4
- Date
- 2018
- Source
- Journal of Zhejiang University. Science. B 19: 25-37 (Journal)
- Registered Authors
- Keywords
- Prediction; Gene regulatory relationships; Order of gene location; Spatio-temporal neighborhood method; Zebrafish cardiogenesis
- MeSH Terms
-
- Algorithms
- Animals
- Chromosome Mapping*
- Chromosomes
- Gene Expression
- Gene Regulatory Networks*
- Heart/diagnostic imaging
- Heart/embryology
- Heart/physiology
- Zebrafish/genetics*
- PubMed
- 29308605 Full text @ J. Zhejiang Univ. Sci. B
Citation
Meng, J., Xu, W.Y., Chen, X., Lin, T., Deng, X.Y. (2018) Gene locations may contribute to predicting gene regulatory relationships. Journal of Zhejiang University. Science. B. 19:25-37.
Abstract
We propose that locations of genes on chromosomes can contribute to the prediction of gene regulatory relationships. We constructed a time-based gene regulatory network of zebrafish cardiogenesis on the basis of a spatio-temporal neighborhood method. Through the network, specific regulatory pathways and order of gene expression during zebrafish cardiogenesis were obtained. By comparing the order with locations of these genes on chromosomes, we discovered that there exists a reversal phenomenon between the order and order of gene locations. The discovery provides an inherent rule to instruct exploration of gene regulatory relationships. Specifically, the discovery can help to predict if regulatory relationships between genes exist and contribute to evaluating the correctness of discovered gene regulatory relationships.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping