PUBLICATION
Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents
- Authors
- Pagire, S.H., Lee, E., Pagire, H.S., Bae, E.J., Ryu, S.J., Lee, D., Kim, M.H., Kim, G.R., Hwang, K.S., Ahn, S., Maeng, J.H., Song, J.S., Bae, M.A., Lee, D.H., Ahn, J.H.
- ID
- ZDB-PUB-180104-2
- Date
- 2017
- Source
- Bioorganic & medicinal chemistry letters 28(3): 529-532 (Journal)
- Registered Authors
- Lee, Eun-Hye
- Keywords
- Antioxidant, Glutamic acid derivatives, Ramalin
- MeSH Terms
-
- Cell Survival/drug effects
- Structure-Activity Relationship
- Lipopolysaccharides/pharmacology
- Antioxidants/chemical synthesis
- Antioxidants/chemistry
- Antioxidants/pharmacology*
- Biphenyl Compounds/antagonists & inhibitors*
- Mice
- Molecular Structure
- Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis
- Anti-Inflammatory Agents, Non-Steroidal/chemistry
- Anti-Inflammatory Agents, Non-Steroidal/pharmacology*
- Picrates/antagonists & inhibitors*
- Dose-Response Relationship, Drug
- Zebrafish
- Animals
- RAW 264.7 Cells
- Glutamic Acid/chemical synthesis
- Glutamic Acid/chemistry
- Glutamic Acid/pharmacology*
- Drug Design*
- PubMed
- 29295794 Full text @ Bioorg. Med. Chem. Lett.
Citation
Pagire, S.H., Lee, E., Pagire, H.S., Bae, E.J., Ryu, S.J., Lee, D., Kim, M.H., Kim, G.R., Hwang, K.S., Ahn, S., Maeng, J.H., Song, J.S., Bae, M.A., Lee, D.H., Ahn, J.H. (2017) Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 28(3):529-532.
Abstract
A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping