PUBLICATION
Environmental concentrations of antibiotics impair zebrafish gut health
- Authors
- Zhou, L., Limbu, S.M., Shen, M., Zhai, W., Qiao, F., He, A., Du, Z.Y., Zhang, M.
- ID
- ZDB-PUB-180102-5
- Date
- 2017
- Source
- Environmental pollution (Barking, Essex : 1987) 235: 245-254 (Journal)
- Registered Authors
- Du, Zhen-Yu, Limbu, Samwel Michele, Qiao, Fang, Zhang, Mei-Ling
- Keywords
- Antibiotic, Gut health, Intestinal microbiota, Zebrafish
- MeSH Terms
-
- Anti-Bacterial Agents/toxicity*
- Humans
- Oxytetracycline/toxicity
- Sulfamethoxazole/toxicity
- Zebrafish/metabolism
- Zebrafish/physiology*
- Water Pollutants, Chemical/toxicity*
- Gastrointestinal Microbiome/drug effects*
- Animals
- PubMed
- 29291524 Full text @ Environ. Pollut.
Citation
Zhou, L., Limbu, S.M., Shen, M., Zhai, W., Qiao, F., He, A., Du, Z.Y., Zhang, M. (2017) Environmental concentrations of antibiotics impair zebrafish gut health. Environmental pollution (Barking, Essex : 1987). 235:245-254.
Abstract
Antibiotics have been widely used in human and veterinary medicine to both treat and prevent disease. Due to their high water solubility and low bioavailability, many antibiotic residues have been found in aquatic environments. Fish are an indispensable link between the environmental pollution and human health. However, the chronic effects of environmental concentrations of antibiotics in fish have not been thoroughly investigated. Sulfamethoxazole (SMX) and oxytetracycline (OTC) are frequently detected in aquatic environments. In this study, zebrafish were exposed to SMX (260?ng/L) and OTC (420?ng/L) for a six-week period. Results indicated that exposure to antibiotics did not influence weight gain of fish but increased the metabolic rate and caused higher mortality when treated fish were challenged with Aeromonas hydrophila. Furthermore, exposure to antibiotics in water resulted in a significant decrease in intestinal goblet cell numbers, alkaline phosphatase (AKP), acid phosphatase (ACP) activities, and the anti-oxidant response while there was a significant increase in expression of inflammatory factors. Antibiotic exposure also disturbed the intestinal microbiota in the OTC-exposed group. Our results indicated that environmental antibiotic concentrations can impair the gut health of zebrafish. The potential health risk of antibiotic residues in water should be evaluated in the future.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping