ZFIN ID: ZDB-PUB-171219-14
Macrophage-Microbe Interactions: Lessons from the Zebrafish Model
Yoshida, N., Frickel, E.M., Mostowy, S.
Date: 2017
Source: Frontiers in immunology   8: 1703 (Review)
Registered Authors: Mostowy, Serge
Keywords: host–pathogen interactions, infection, inflammation, macrophage, zebrafish
MeSH Terms: none
PubMed: 29250076 Full text @ Front Immunol
Macrophages provide front line defense against infections. The study of macrophage-microbe interplay is thus crucial for understanding pathogenesis and infection control. Zebrafish (Danio rerio) larvae provide a unique platform to study macrophage-microbe interactions in vivo, from the level of the single cell to the whole organism. Studies using zebrafish allow non-invasive, real-time visualization of macrophage recruitment and phagocytosis. Furthermore, the chemical and genetic tractability of zebrafish has been central to decipher the complex role of macrophages during infection. Here, we discuss the latest developments using zebrafish models of bacterial and fungal infection. We also review novel aspects of macrophage biology revealed by zebrafish, which can potentiate development of new therapeutic strategies for humans.