ZFIN ID: ZDB-PUB-171204-44
Involvement of Lypge in the formation of eye and pineal gland in zebrafish
Ji, D., Wang, S., Li, M., Zhang, S., Li, H.
Date: 2017
Source: Gene   642: 491-497 (Journal)
Registered Authors: Li, Hongyan
Keywords: Ly-6, Photoreceptor, Pineal gland, Zebrafish
MeSH Terms:
  • Animals
  • Cloning, Molecular
  • Eye/embryology*
  • Eye/metabolism
  • GPI-Linked Proteins/chemistry
  • GPI-Linked Proteins/genetics*
  • GPI-Linked Proteins/metabolism*
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Models, Molecular
  • Organ Specificity
  • Otx Transcription Factors/metabolism
  • Phylogeny
  • Pineal Gland/embryology*
  • Pineal Gland/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 29196253 Full text @ Gene
The proteins of Ly-6 (lymphocyte antigen-6) family are involved in the regulation of immunoreaction, cell migration and adhesion, and neuronal excitability. However, little is known about the function of Ly-6 proteins in embryogenesis. Herein, we identified a GPI anchored Ly-6 member named ly6 expressed in pineal gland and eye (lypge). Dynamic expression pattern of lypge was revealed by whole mount in situ hybridization. It was strikingly expressed in the pineal gland and cone photoreceptor, and its expression was regulated by orthodenticle homolog 5 (otx5) which has been shown to control the expression of many pineal genes. In addition, we demonstrated that lypge was rhythmically expressed in larvae from 4dpf on. Moreover, knockdown of lypge resulted in small head and small eye formed in zebrafish embryos. These suggest that Lypge is involved in the formation of the eye and pineal gland in early development of zebrafish.