PUBLICATION
Lithium prevents scopolamine-induced memory impairment in zebrafish
- Authors
- Zanandrea, R., Abreu, M.S., Piato, A., Barcellos, L.J.G., Giacomini, A.C.V.V.
- ID
- ZDB-PUB-171113-9
- Date
- 2017
- Source
- Neuroscience letters 664: 34-37 (Journal)
- Registered Authors
- Keywords
- Acetylcholinesterase, Alzheimer's disease, Anxiety, Cognition, Memory
- MeSH Terms
-
- Cholinesterase Inhibitors/pharmacology
- Cholinesterase Inhibitors/therapeutic use
- Enzyme Inhibitors/pharmacology
- Enzyme Inhibitors/therapeutic use
- Motor Activity/drug effects
- Motor Activity/physiology
- Female
- Male
- Dose-Response Relationship, Drug
- Scopolamine/toxicity*
- Lithium Carbonate/pharmacology
- Lithium Carbonate/therapeutic use*
- Zebrafish
- Muscarinic Antagonists/toxicity
- Animals
- Antidepressive Agents/pharmacology
- Antidepressive Agents/therapeutic use
- Memory Disorders/chemically induced*
- Memory Disorders/prevention & control*
- Memory Disorders/psychology
- Maze Learning/drug effects*
- Maze Learning/physiology
- PubMed
- 29126775 Full text @ Neurosci. Lett.
Citation
Zanandrea, R., Abreu, M.S., Piato, A., Barcellos, L.J.G., Giacomini, A.C.V.V. (2017) Lithium prevents scopolamine-induced memory impairment in zebrafish. Neuroscience letters. 664:34-37.
Abstract
We examined whether lithium carbonate (Li2CO3, 100mg/L) is able to prevent memory impairment induced by scopolamine. Moreover, we evaluated the effects of lithium on anxiety-like behavior and acetylcholinesterase activity in adult zebrafish. We demonstrated that lithium prevents the memory impairment induced by scopolamine, decreases exploration and increases the activity of acetylcholinesterase in zebrafish. Collectively, this contributes to a better understanding of the pharmacology of lithium, its interaction with cholinergic neurotransmission, and its possible application to therapeutic treatments aimed at improving cognition.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping