PUBLICATION
Acute developmental exposure to 4-hydroxyandrostenedione has a long-term effect on visually-guided behaviors
- Authors
- Gould, C.J., Wiegand, J.L., Connaughton, V.P.
- ID
- ZDB-PUB-171017-9
- Date
- 2017
- Source
- Neurotoxicology and teratology 64: 45-49 (Journal)
- Registered Authors
- Connaughton, Victoria P.
- Keywords
- 4-OH-A, EDCs, Endocrine disruptors, OMR, Optomotor response, Zebrafish
- MeSH Terms
-
- Androstenedione/administration & dosage
- Androstenedione/analogs & derivatives*
- Animals
- Aromatase Inhibitors/administration & dosage*
- Behavior, Animal/drug effects
- Embryo, Nonmammalian/drug effects
- Embryonic Development/drug effects*
- Endocrine Disruptors/administration & dosage*
- Photic Stimulation
- Psychomotor Performance/drug effects*
- Vision, Ocular/drug effects*
- Visual Perception/drug effects
- Zebrafish
- PubMed
- 29031477 Full text @ Neurotoxicol. Teratol.
Citation
Gould, C.J., Wiegand, J.L., Connaughton, V.P. (2017) Acute developmental exposure to 4-hydroxyandrostenedione has a long-term effect on visually-guided behaviors. Neurotoxicology and teratology. 64:45-49.
Abstract
Estrogenic and anti-estrogenic endocrine disrupting compounds (EDCs) are recognized as critical modulators of neural development, including sensory system development. Using the zebrafish model, we tested the effect of transient developmental exposure to a known anti-estrogenic EDC on adult visually-guided behavior. In particular, we exposed zebrafish aged 24-hour post-fertilization (hpf), 72 hpf, or 7-days post-fertilization (dpf) to the aromatase inhibitor 4-hydroxyandrostenedione (4-OH-A) for 24h. After this time, the fish were removed from treatment, placed into control conditions, and reared until adulthood (3-4months) when visually-guided optomotor responses (OMR) were assessed. Our results show significant decreases in positive OMR in adults exposed to 4-OH-A at 72 hpf and 7 dpf. These deficits were not accompanied by changes in overall swimming behaviors and startle responses, suggesting 4-OH-A specifically effected the visual system. Overall, this study identified long-term, quantifiable effects in visually-guided adult behaviors resulting from transient developmental exposure to the anti-estrogenic EDC, 4-OH-A. Further, these effects were noted when 4-OH-A exposure occurred after hatching, suggesting estrogen signaling is important for visual system maturation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping