PUBLICATION

A Zebrafish Model of Mycobacterium leprae Granulomatous Infection

Authors
Madigan, C.A., Cameron, J., Ramakrishnan, L.
ID
ZDB-PUB-170922-4
Date
2017
Source
The Journal of infectious diseases   216: 776-779 (Journal)
Registered Authors
Cameron, James, Madigan, Cressida, Ramakrishnan, Lalita
Keywords
granuloma, leprosy, mycobacteria, zebrafish
MeSH Terms
  • Mycobacterium leprae*
  • Leprosy/microbiology*
  • Zebrafish
  • Male
  • Animals
  • Granuloma/microbiology*
  • Disease Models, Animal*
(all 7)
PubMed
28934421 Full text @ J. Infect. Dis.
Abstract
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at approximately 30°C, so we sought to model granulomatous disease in the ectothermic zebrafish. We found that noncaseating granulomas develop rapidly and eventually eradicate infection. rag1 mutant zebrafish, which lack lymphocytes, also form noncaseating granulomas with similar kinetics, but these control infection more slowly. Our findings establish the zebrafish as a facile, genetically tractable model for leprosy and reveal the interplay between innate and adaptive immune determinants mediating leprosy granuloma formation and function.
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Citation
Madigan, C.A., Cameron, J., Ramakrishnan, L. (2017) A Zebrafish Model of Mycobacterium leprae Granulomatous Infection. The Journal of infectious diseases. 216:776-779.