PUBLICATION
Anti-inflammatory Effects of Galactose-Taurine Sodium Salt: A Taurine Derivate in Zebrafish In Vivo Model
- Authors
- Kim, E.A., Lee, W., Um, J.H., Kang, N., Cheong, S.H., Oh, J.Y., Chang, K.J., Kim, S.H., Park, S.Y., Han, E.J., Jeon, Y.J., Ahn, G.
- ID
- ZDB-PUB-170830-8
- Date
- 2017
- Source
- Advances in experimental medicine and biology 975: 655-666 (Journal)
- Registered Authors
- Jeon, You-Jin
- Keywords
- Anti-inflammatory effect, Galactose-Taurine sodium salt, Macrophages, Zebrafish
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/pharmacology*
- Embryo, Nonmammalian
- Galactose/pharmacology*
- Inflammation Mediators/metabolism
- Reactive Oxygen Species/metabolism
- Taurine/pharmacology*
- Zebrafish
- PubMed
- 28849489 Full text @ Adv. Exp. Med. Biol.
Citation
Kim, E.A., Lee, W., Um, J.H., Kang, N., Cheong, S.H., Oh, J.Y., Chang, K.J., Kim, S.H., Park, S.Y., Han, E.J., Jeon, Y.J., Ahn, G. (2017) Anti-inflammatory Effects of Galactose-Taurine Sodium Salt: A Taurine Derivate in Zebrafish In Vivo Model. Advances in experimental medicine and biology. 975:655-666.
Abstract
Taurine, the plentiful amino acids in mammalian cells exerts various biological activities including antioxidant and anti-inflammatory effects. Inflammation can cause several diseases such as cancer, heart disease, rheumatoid arthritis and immune system reactions. Here, we investigated anti-inflammatory effects of Galactose-Taurine sodium salt (Gal-Tau), a newly synthesized taurine derivate in LPS-stimulated zebrafish embryos in vivo model. The result showed that Gal-Tau improved the survival rate and the edema in LPS-treated zebrafish embryos. Also, Gal-Tau effectively reduced the productions of nitric oxide (NO), reactive oxygen species (ROS) and cell death induced by LPS in zebrafish embryos. In addition, Gal-Tau regulated the expression levels of inflammatory mediators such as inducible NOS (iNOS) and cycloxygenase 2 (COX-2) as well as IL-6 and TNF-α, inflammatory cytokines known as important key mediators of inflammation. Taken together, this study first indicates that Gal-Tau could be considered as an effective anti-inflammatory material with its anti-inflammatory activity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping