PUBLICATION
The Chordin Morphogenetic Pathway
- Authors
- De Robertis, E.M., Moriyama, Y.
- ID
- ZDB-PUB-170829-9
- Date
- 2016
- Source
- Current topics in developmental biology 116: 231-45 (Chapter)
- Registered Authors
- De Robertis, Eddy
- Keywords
- BMP, Chordin, Gradient, Morphogen, Self-organization, Sizzled, Tolloid
- MeSH Terms
-
- Animals
- Bone Morphogenetic Proteins/metabolism*
- Cloning, Molecular
- Drosophila Proteins/genetics
- Drosophila Proteins/metabolism
- Embryo, Nonmammalian
- GTPase-Activating Proteins/genetics
- GTPase-Activating Proteins/metabolism
- Glycoproteins/genetics
- Glycoproteins/metabolism*
- Intercellular Signaling Peptides and Proteins/genetics
- Intercellular Signaling Peptides and Proteins/metabolism*
- Morphogenesis/physiology*
- Signal Transduction
- Tolloid-Like Metalloproteinases/genetics
- Tolloid-Like Metalloproteinases/metabolism
- Xenopus/embryology
- Xenopus/metabolism
- Xenopus Proteins/genetics
- Xenopus Proteins/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 26970622 Full text @ Curr. Top. Dev. Biol.
Citation
De Robertis, E.M., Moriyama, Y. (2016) The Chordin Morphogenetic Pathway. Current topics in developmental biology. 116:231-45.
Abstract
The ancestral Chordin/bone morphogenetic protein (BMP) signaling pathway that establishes dorsal-ventral (D-V) patterning in animal development is one of the best understood morphogenetic gradients, and is established by multiple proteins that interact with each other in the extracellular space-including several BMPs, Chordin, Tolloid, Ont-1, Crossveinless-2, and Sizzled. The D-V gradient is adjusted redundantly by regulating the synthesis of its components, by direct protein-protein interactions between morphogens, and by long-range diffusion. The entire embryo participates in maintaining the D-V BMP gradient, so that for each action in the dorsal side there is a reaction in the ventral side. A gradient of Chordin is formed in the extracellular matrix that separates ectoderm from endomesoderm, called Brachet's cleft in Xenopus. The Chordin/BMP pathway is self-organizing and able to scale pattern in the dorsal half of bisected embryos or in Spemann dorsal lip transplantation experiments.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping