PUBLICATION
Zygotic Genome Activators, Developmental Timing, and Pluripotency
- Authors
- Onichtchouk, D., Driever, W.
- ID
- ZDB-PUB-170829-8
- Date
- 2016
- Source
- Current topics in developmental biology 116: 273-97 (Chapter)
- Registered Authors
- Driever, Wolfgang
- Keywords
- Blastula, Differentiation, Embryo, Embryonic stem cells, Gene regulatory network, Oct4, Pattern formation, Pluripotency, Pou5f3, Zygotic genome activation
- MeSH Terms
-
- Animals
- Zebrafish/embryology
- Zebrafish/genetics
- Gene Regulatory Networks*
- Mammals/embryology
- Mammals/genetics
- Evolution, Molecular
- Female
- Zygote*
- Cell Lineage
- Octamer Transcription Factor-3/genetics
- Octamer Transcription Factor-3/metabolism
- Gene Expression Regulation, Developmental*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Humans
- Nanog Homeobox Protein/genetics
- Nanog Homeobox Protein/metabolism
- Pluripotent Stem Cells*
- PubMed
- 26970624 Full text @ Curr. Top. Dev. Biol.
Citation
Onichtchouk, D., Driever, W. (2016) Zygotic Genome Activators, Developmental Timing, and Pluripotency. Current topics in developmental biology. 116:273-97.
Abstract
The transcription factors Pou5f1, Sox2, and Nanog are central regulators of pluripotency in mammalian ES and iPS cells. In vertebrate embryos, Pou5f1/3, SoxB1, and Nanog control zygotic genome activation and participate in lineage decisions. We review the current knowledge of the roles of these genes in developing vertebrate embryos from fish to mammals and suggest a model for pluripotency gene regulatory network functions in early development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping