PUBLICATION
Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
- Authors
- Perlin, J.R., Robertson, A.L., Zon, L.I.
- ID
- ZDB-PUB-170824-14
- Date
- 2017
- Source
- The Journal of experimental medicine 214(10): 2817-2827 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Hematopoiesis/physiology*
- Hematopoietic Stem Cell Transplantation*
- Stem Cells/physiology
- Zebrafish/physiology*
- PubMed
- 28830909 Full text @ J. Exp. Med.
Citation
Perlin, J.R., Robertson, A.L., Zon, L.I. (2017) Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. The Journal of experimental medicine. 214(10):2817-2827.
Abstract
Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro. There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment. Recent studies in zebrafish have revealed novel genes that are required for HSC induction and niche regulation of HSC homeostasis. Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping