PUBLICATION
Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect
- Authors
- Meng, C.W., He, Y.L., Peng, C., Ding, X.J., Guo, L., Xiong, L.
- ID
- ZDB-PUB-170806-7
- Date
- 2017
- Source
- Fitoterapia 121: 206-211 (Journal)
- Registered Authors
- Keywords
- Absolute configuration, Angiogenesis effect, Dendrobium nobile, Picrotoxane, Sesquiterpenoids, Transgenic zebrafish
- MeSH Terms
-
- Alkaloids/isolation & purification
- Alkaloids/pharmacology*
- Angiogenesis Inducing Agents/isolation & purification
- Angiogenesis Inducing Agents/pharmacology*
- Animals
- Animals, Genetically Modified
- Dendrobium/chemistry*
- Molecular Structure
- Plant Stems/chemistry
- Sesquiterpenes/isolation & purification
- Sesquiterpenes/pharmacology*
- Zebrafish
- PubMed
- 28778562 Full text @ Fitoterapia
Citation
Meng, C.W., He, Y.L., Peng, C., Ding, X.J., Guo, L., Xiong, L. (2017) Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect. Fitoterapia. 121:206-211.
Abstract
Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium nobile Lindl. Their structures were established by spectroscopic analyses and physical properties. Compound 1 was a new dendrobine analogue. Although the planar structure of 2 and 3 had been reported, their absolute configurations were first determined by single-crystal X-ray diffraction and circular dichroism. Compound 2 exhibited angiogenesis effect against sunitinib-induced damage on intersegmental blood vessels in Tg (flk1: EGFP) and Tg (fli1: nEGFP) transgenic zebrafish at concentrations of 3.13, 6.25, 12.50, and 25.00μM.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping