PUBLICATION
Parkinson's disease pathogenesis from the viewpoint of small fish models
- Authors
- Matsui, H., Takahashi, R.
- ID
- ZDB-PUB-170805-17
- Date
- 2017
- Source
- Journal of neural transmission (Vienna, Austria : 1996) 125(1): 25-33 (Review)
- Registered Authors
- Matsui, Hideaki
- Keywords
- Lysosome dysfunction, Medaka, Mitochondrial dysfunction, Parkinson?s disease, Zebrafish
- MeSH Terms
-
- Oryzias
- Animals
- Disease Models, Animal*
- Humans
- Parkinson Disease/metabolism*
- Parkinson Disease/pathology
- Zebrafish
- Parkinsonian Disorders/metabolism
- Parkinsonian Disorders/pathology
- Lysosomes/metabolism*
- Lysosomes/pathology
- Mitochondria/metabolism*
- Mitochondria/pathology
- Dopaminergic Neurons/metabolism
- Dopaminergic Neurons/pathology
- PubMed
- 28770388 Full text @ J. Neural Transm.
Citation
Matsui, H., Takahashi, R. (2017) Parkinson's disease pathogenesis from the viewpoint of small fish models. Journal of neural transmission (Vienna, Austria : 1996). 125(1):25-33.
Abstract
Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a new model for Parkinson disease. In this review, we summarize fish models of Parkinson's disease mainly using our own findings and explain two major hypotheses of PD: lysosome dysfunction theory and mitochondrial dysfunction theory. Finally, we discuss the potential for future application of small fish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping