PUBLICATION

Parkinson's disease pathogenesis from the viewpoint of small fish models

Authors
Matsui, H., Takahashi, R.
ID
ZDB-PUB-170805-17
Date
2017
Source
Journal of neural transmission (Vienna, Austria : 1996)   125(1): 25-33 (Review)
Registered Authors
Matsui, Hideaki
Keywords
Lysosome dysfunction, Medaka, Mitochondrial dysfunction, Parkinson’s disease, Zebrafish
MeSH Terms
  • Animals
  • Disease Models, Animal*
  • Dopaminergic Neurons/metabolism
  • Dopaminergic Neurons/pathology
  • Humans
  • Lysosomes/metabolism*
  • Lysosomes/pathology
  • Mitochondria/metabolism*
  • Mitochondria/pathology
  • Oryzias
  • Parkinson Disease/metabolism*
  • Parkinson Disease/pathology
  • Parkinsonian Disorders/metabolism
  • Parkinsonian Disorders/pathology
  • Zebrafish
PubMed
28770388 Full text @ J. Neural Transm.
Abstract
Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a new model for Parkinson disease. In this review, we summarize fish models of Parkinson's disease mainly using our own findings and explain two major hypotheses of PD: lysosome dysfunction theory and mitochondrial dysfunction theory. Finally, we discuss the potential for future application of small fish model.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping