PUBLICATION
Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry
- Authors
- Das, D., Chatti, V., Emonet, T., Holley, S.A.
- ID
- ZDB-PUB-170726-2
- Date
- 2017
- Source
- Developmental Cell 42: 170-180.e5 (Journal)
- Registered Authors
- Holley, Scott
- Keywords
- biomechanics, body elongation, cadherin, collective cell migration, noise regulation, notum, scoliosis, symmetry breaking, systems biology, zebrafish
- MeSH Terms
-
- Animals
- Body Patterning*
- Cell Movement*
- Computer Simulation
- Models, Biological
- Spine/cytology*
- Spine/embryology*
- Tail/embryology
- Zebrafish/embryology*
- Zebrafish Proteins/metabolism
- PubMed
- 28743003 Full text @ Dev. Cell
Citation
Das, D., Chatti, V., Emonet, T., Holley, S.A. (2017) Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry. Developmental Cell. 42:170-180.e5.
Abstract
The biomechanics of posterior embryonic growth must be dynamically regulated to ensure bilateral symmetry of the spinal column. Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder transition via an epithelial-to-mesenchymal transition and sort symmetrically into the left and right paraxial mesoderm. We combine theoretical modeling of cell migration in a tail-bud-like geometry with experimental data analysis to assess the importance of ordered and disordered cell motion. We find that increasing order in cell motion causes a phase transition from symmetric to asymmetric body elongation. In silico and in vivo, overly ordered cell motion converts normal anisotropic fluxes into stable vortices near the posterior tail bud, contributing to asymmetric cell sorting. Thus, disorder is a physical mechanism that ensures the bilateral symmetry of the spinal column. These physical properties of the tissue connect across scales such that patterned disorder at the cellular level leads to the emergence of organism-level order.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping