PUBLICATION
Insights from zebrafish on human pigment cell disease and treatment
- Authors
- Cooper, C.D.
- ID
- ZDB-PUB-170716-2
- Date
- 2017
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 246(11): 889-896 (Review)
- Registered Authors
- Cooper, Cynthia
- Keywords
- chemoresistance, melanocyte, melanophore, skin, zebrafish
- MeSH Terms
-
- Animals
- Humans
- Melanocytes/cytology
- Melanocytes/pathology*
- Melanoma
- Melanophores/cytology
- Melanophores/pathology
- Pigmentation/genetics*
- Zebrafish
- PubMed
- 28710811 Full text @ Dev. Dyn.
Citation
Cooper, C.D. (2017) Insights from zebrafish on human pigment cell disease and treatment. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(11):889-896.
Abstract
Black pigment cells, melanocytes, arise early during development from multipotent neural crest cells. Melanocytes protect human skin from DNA damaging sunrays and provide color for hair, eyes and skin. Several disorders and diseases originate from these cells, including the deadliest skin cell cancer, melanoma. Thus, melanocytes are critical for a healthy life and for protecting humans from disease. Due to the ease of visualizing pigment cells through transparent larvae skin and conserved roles for zebrafish melanophore genes to mammalian melanocyte genes, zebrafish larvae offer a biologically relevant model for understanding pigment cell development and disease in humans. This review discusses our current knowledge of melanophore biology and how zebrafish are contributing to improving how diseases of melanocytes are understood and treated in humans. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping