PUBLICATION
Studying Autophagy in Zebrafish
- Authors
- Mathai, B.J., Meijer, A.H., Simonsen, A.
- ID
- ZDB-PUB-170713-6
- Date
- 2017
- Source
- Cells 6(3): 21 (Review)
- Registered Authors
- Meijer, Annemarie H., Simonsen, Anne
- Keywords
- GFP-Lc3, aggrephagy, autophagy, confocal microscopy, mitophagy, xenophagy, zebrafish
- MeSH Terms
- none
- PubMed
- 28698482 Full text @ Cells
Citation
Mathai, B.J., Meijer, A.H., Simonsen, A. (2017) Studying Autophagy in Zebrafish. Cells. 6(3):21.
Abstract
Autophagy is an evolutionarily conserved catabolic process which allows lysosomal degradation of complex cytoplasmic components into basic biomolecules that are recycled for further cellular use. Autophagy is critical for cellular homeostasis and for degradation of misfolded proteins and damaged organelles as well as intracellular pathogens. The role of autophagy in protection against age-related diseases and a plethora of other diseases is now coming to light; assisted by several divergent eukaryotic model systems ranging from yeast to mice. We here give an overview of different methods used to analyse autophagy in zebrafish-a relatively new model for studying autophagy-and briefly discuss what has been done so far and possible future directions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping