PUBLICATION
The morphological influence of human TCP10L microinjected in zebrafish
- Authors
- Wang, L., Yao, J., Cheng, L., Chen, L., Ruan, Z., Xue, J.
- ID
- ZDB-PUB-170612-5
- Date
- 2007
- Source
- The Journal of Fudan University (Natural Science) 46(3): 371-376 (Journal)
- Registered Authors
- Wang, Lu, Yao, Jihua
- Keywords
- zebrafish, liver specific transcription factor, over-expression, cardiovascular system, morphological defects
- MeSH Terms
- none
- PubMed
- none
Citation
Wang, L., Yao, J., Cheng, L., Chen, L., Ruan, Z., Xue, J. (2007) The morphological influence of human TCP10L microinjected in zebrafish. The Journal of Fudan University (Natural Science). 46(3):371-376.
Abstract
To investigate the influence of human liver specific transcription factor TCP10L in zebrafish embryonic development,TCP10L was over-expressed in zebrafish embryos by microinjection and morphology alterations of larval zebrafish were observed.The results indicated that TCP10L was toxic to zebrafish embryonic development.Most larval zebrafish displayed morphological defects,including abnormal dorsal chord,deformed body and cardiovascular abnormality(slow bloodstream and pericardial cavity edema).The results provide evidence that over-expression of TCP10L in zebrafish embryos can cause morphological defects and cardiovascular abnormality.The effects are related to whether TCP10L is specifically expressed in the zebrafish liver.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping