PUBLICATION
Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod
- Authors
- Tulenko, F.J., Massey, J.L., Holmquist, E., Kigundu, G., Thomas, S., Smith, S.M.E., Mazan, S., Davis, M.C.
- ID
- ZDB-PUB-170526-9
- Date
- 2017
- Source
- Proceedings. Biological sciences 284(1855): (Journal)
- Registered Authors
- Tulenko, Frank
- Keywords
- AER, HoxA, autopod, catshark, fin-fold, paddlefish
- MeSH Terms
-
- Animal Fins/physiology*
- Animals
- Fishes/anatomy & histology*
- Gene Expression Regulation, Developmental
- Homeodomain Proteins/genetics
- Homeodomain Proteins/physiology*
- Mesoderm
- Phylogeny
- Sharks/anatomy & histology*
- Zebrafish
- PubMed
- 28539509 Full text @ Proc. Biol. Sci.
Citation
Tulenko, F.J., Massey, J.L., Holmquist, E., Kigundu, G., Thomas, S., Smith, S.M.E., Mazan, S., Davis, M.C. (2017) Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod. Proceedings. Biological sciences. 284(1855).
Abstract
The evolutionary origin of the autopod involved a loss of the fin-fold and associated dermal skeleton with a concomitant elaboration of the distal endoskeleton to form a wrist and digits. Developmental studies, primarily from teleosts and amniotes, suggest a model for appendage evolution in which a delay in the AER-to-fin-fold conversion fuelled endoskeletal expansion by prolonging the function of AER-mediated regulatory networks. Here, we characterize aspects of paired fin development in the paddlefish Polyodon spathula (a non-teleost actinopterygian) and catshark Scyliorhinus canicula (chondrichthyan) to explore aspects of this model in a broader phylogenetic context. Our data demonstrate that in basal gnathostomes, the autopod marker HoxA13 co-localizes with the dermoskeleton component And1 to mark the position of the fin-fold, supporting recent work demonstrating a role for HoxA13 in zebrafish fin ray development. Additionally, we show that in paddlefish, the proximal fin and fin-fold mesenchyme share a common mesodermal origin, and that components of the Shh/LIM/Gremlin/Fgf transcriptional network critical to limb bud outgrowth and patterning are expressed in the fin-fold with a profile similar to that of tetrapods. Together these data draw contrast with hypotheses of AER heterochrony and suggest that limb-specific morphologies arose through evolutionary changes in the differentiation outcome of conserved early distal patterning compartments.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping