ZFIN ID: ZDB-PUB-170426-7
Nuclear receptor research in zebrafish
Schaaf, M.J.M.
Date: 2017
Source: Journal of molecular endocrinology   59: R65-R76 (Review)
Registered Authors: Schaaf, Marcel J. M.
Keywords: zebrafish, nuclear receptor, estrogen receptor, retinoic acid receptor, peroxisome proliferator-activated receptor
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Gene Expression Regulation
  • Gene Ontology
  • Humans
  • Ligands
  • Models, Animal
  • Molecular Sequence Annotation
  • Peroxisome Proliferator-Activated Receptors/classification
  • Peroxisome Proliferator-Activated Receptors/genetics*
  • Phylogeny
  • Polymorphism, Genetic*
  • Receptors, Estrogen/classification
  • Receptors, Estrogen/genetics*
  • Receptors, Retinoic Acid/classification
  • Receptors, Retinoic Acid/genetics*
  • Signal Transduction
  • Zebrafish/classification
  • Zebrafish/genetics*
PubMed: 28438785 Full text @ J. Mol. Endocrinol.
Nuclear receptors (NRs) form a superfamily of transcription factors that can be activated by ligands and are involved in a wide range of physiological processes. NRs are well conserved between vertebrate species. The zebrafish, an increasingly popular animal model system, contains a total of 73 NR genes, and orthologues of almost all human NRs are present. In this review article, an overview is presented of NR research in which the zebrafish has been used as a model. Research is described on the three most studied zebrafish NRs: the Estrogen Receptors (ERs), Retinoic Acid Receptors (RARs) and Peroxisome Proliferator-Activated Receptors (PPARs). The studies on these receptors illustrate the versatility of the zebrafish as a model for ecotoxicological, developmental and biomedical research. Although the use of the zebrafish in NR research is still relatively limited, it is expected that in the next decade the full potential of this animal model will be exploited.