ZFIN ID: ZDB-PUB-170410-7
Zebrafish sleep: from geneZZZ to neuronZZZ
Barlow, I.L., Rihel, J.
Date: 2017
Source: Current opinion in neurobiology   44: 65-71 (Review)
Registered Authors: Barlow, Ida, Rihel, Jason
Keywords: none
MeSH Terms:
  • Animals
  • Arousal/genetics
  • Models, Animal
  • Sleep/genetics*
  • Zebrafish/genetics*
PubMed: 28391130 Full text @ Curr. Opin. Neurobiol.
All animals have a fundamental and unavoidable requirement for rest, yet we still do not fully understand the processes that initiate, maintain, and regulate sleep. The larval zebrafish is an optically translucent, genetically tractable model organism that exhibits sleep states regulated by conserved sleep circuits, thereby offering a unique system for investigating the genetic and neural control of sleep. Recent studies using high throughput monitoring of larval sleep/wake behaviour have unearthed novel modulators involved in regulating arousal and have provided new mechanistic insights into the role of established sleep/wake modulators. In addition, the application of computational tools to large behavioural datasets has allowed for the identification of neuroactive compounds that alleviate sleep symptoms associated with genetic neurological disorders.