ZFIN ID: ZDB-PUB-170406-4
From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics
van Rooijen, E., Fazio, M., Zon, L.I.
Melanoma is the most aggressive and deadliest form of skin cancer. A detailed knowledge of the cellular, molecular and genetic events underlying melanoma progression is highly relevant to diagnosis, prognosis and risk stratification, and the development of new therapies. In the last decade, zebrafish have emerged as a valuable model system for the study of melanoma. Pathway conservation, coupled with the availability of robust genetic, transgenic and chemical tools, has made the zebrafish a powerful model for identifying novel disease genes, visualizing cancer initiation, interrogating tumor-microenvironment interactions and discovering new therapeutics that regulate melanocyte and melanoma development. In this review, we will give an overview of these studies, and highlight recent advancements that will help unravel melanoma pathogenesis and impact human disease. This article is protected by copyright. All rights reserved.
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