PUBLICATION
Friction forces position the neural anlage
- Authors
- Smutny, M., Ákos, Z., Grigolon, S., Shamipour, S., Ruprecht, V., Čapek, D., Behrndt, M., Papusheva, E., Tada, M., Hof, B., Vicsek, T., Salbreux, G., Heisenberg, C.P.
- ID
- ZDB-PUB-170328-2
- Date
- 2017
- Source
- Nature cell biology 19(4): 306-317 (Journal)
- Registered Authors
- Behrndt, Martin, Heisenberg, Carl-Philipp, Ruprecht, Verena, Smutny, Michael, Tada, Masazumi
- Keywords
- none
- MeSH Terms
-
- Animals
- Biomechanical Phenomena
- Cadherins/metabolism
- Cell Communication
- Cell Movement
- Embryo, Nonmammalian/cytology
- Endoderm/cytology
- Endoderm/embryology
- Friction*
- Gastrulation
- Hydrodynamics
- Mesoderm/cytology
- Mesoderm/embryology
- Models, Biological
- Morphogenesis
- Mutation/genetics
- Nervous System/embryology*
- Neural Plate/cytology
- Neural Plate/embryology
- Zebrafish/embryology*
- Zebrafish Proteins/metabolism
- PubMed
- 28346437 Full text @ Nat. Cell Biol.
Citation
Smutny, M., Ákos, Z., Grigolon, S., Shamipour, S., Ruprecht, V., Čapek, D., Behrndt, M., Papusheva, E., Tada, M., Hof, B., Vicsek, T., Salbreux, G., Heisenberg, C.P. (2017) Friction forces position the neural anlage. Nature cell biology. 19(4):306-317.
Abstract
During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between those tissues. Our data thus establish the emergence of friction forces at the interface between moving tissues as a critical force-generating process shaping the embryo.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping