PUBLICATION

Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish

Authors
Kwan, W., North, T.E.
ID
ZDB-PUB-170326-14
Date
2017
Source
Current topics in developmental biology   124: 125-160 (Chapter)
Registered Authors
North, Trista
Keywords
Hematological disease, Hematopathology, Hematopoiesis, Hematopoietic stem cell, Zebrafish
MeSH Terms
  • Animals
  • Disease Models, Animal
  • Hematologic Neoplasms/pathology*
  • Hematopoiesis*
  • Hematopoietic Stem Cells/cytology
  • Hematopoietic System/embryology
  • Zebrafish/embryology
  • Zebrafish/physiology*
PubMed
28335858 Full text @ Curr. Top. Dev. Biol.
Abstract
Zebrafish are one of the preeminent model systems for the study of blood development (hematopoiesis), hematopoietic stem and progenitor cell (HSPC) biology, and hematopathology. The zebrafish hematopoietic system shares strong similarities in functional populations, genetic regulators, and niche interactions with its mammalian counterparts. These evolutionarily conserved characteristics, together with emerging technologies in live imaging, compound screening, and genetic manipulation, have been employed to successfully identify and interrogate novel regulatory mechanisms and molecular pathways that guide hematopoiesis. Significantly, perturbations in many of the key developmental signals controlling hematopoiesis are associated with hematological disorders and disease, including anemia, bone marrow failure syndromes, and leukemia. Thus, understanding the regulatory pathways controlling HSPC production and function has important clinical implications. In this review, we describe how the blood system forms and is maintained in zebrafish, with particular focus on new insights into vertebrate hematological regulation gained using this model. The interplay of factors controlling development and disease in the hematopoietic system combined with the unique attributes of the zebrafish make this a powerful platform to discover novel targets for the treatment of hematological disease.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes