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ZFIN ID: ZDB-PUB-170323-18
Molecular physiology of the hypocalcemic action of fibroblast growth factor 23 in zebrafish (Danio rerio)
Lin, C.H., Hu, H.J., Hwang, P.P.
Date: 2017
Source: Endocrinology   158(5): 1347-1358 (Journal)
Registered Authors: Hwang, Pung Pung
Keywords: rna, messenger, zebrafish, fibroblast growth factor 23
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Calcium/metabolism*
  • Calcium Signaling/genetics*
  • Embryo, Nonmammalian
  • Fibroblast Growth Factors/genetics*
  • Fibroblast Growth Factors/metabolism
  • Gene Expression Regulation, Developmental
  • Gene Knockdown Techniques
  • Glycoproteins/genetics
  • Glycoproteins/metabolism
  • Hypocalcemia/genetics*
  • Hypocalcemia/metabolism
  • Receptors, Calcium-Sensing/genetics
  • Receptors, Calcium-Sensing/metabolism
  • Signal Transduction/genetics
  • Zebrafish*/embryology
  • Zebrafish*/genetics
  • Zebrafish*/metabolism
PubMed: 28323996 Full text @ Endocrinology
Fibroblast growth factor 23 (FGF23), a hormone required for phosphorus metabolism, was recently proposed to act on Ca2+ uptake; however, the available evidences of how FGF23 controls the body fluid Ca2+ homeostasis needs to be further clarified. The use of zebrafish as a model system revealed that FGF23 is specifically expressed in the corpuscles of Stannius (CS), an organ involved in Ca2+ homeostasis in fish, and its expression is stimulated by ambient water with a high Ca2+ level. The overexpression of FGF23 inhibited Ca2+ uptake by downregulating the mRNA expression of epithelium calcium channel (ECaC). Calcium-sensing receptor (CaSR), which senses changes in extracellular Ca2+ levels and modulates calciotropic hormones in organs controlling Ca2+ homeostasis in vertebrates, was found to be co-expressed with FGF23 in the CS. In addition, upregulated expression of FGF23 mRNA was detected in morphants of stanniocalcin 1 (stc1, another hypocalcemic factor synthesized in the CS), and knockdown of CaSR suppressed such upregulation and enhanced Ca2+ uptake. Taken together, our data indicate that FGF23 functions as a hypocalcemic hormone in zebrafish, and that the CaSR/STC1-FGF23 axis is involved in body fluid Ca2+ homeostasis in vertebrates.