PUBLICATION
Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio
- Authors
- Duan, Z., Xing, Y., Feng, Z., Zhang, H., Li, C., Gong, Z., Wang, L., Sun, H.
- ID
- ZDB-PUB-170306-2
- Date
- 2017
- Source
- Environmental pollution (Barking, Essex : 1987) 224: 706-713 (Journal)
- Registered Authors
- Keywords
- Benzotriazole, Cadmium, Complexation, Hepatotoxicity, Zebrafish
- MeSH Terms
-
- Liver/drug effects*
- Triazoles/toxicity*
- Metals, Heavy/metabolism
- Cadmium/metabolism
- Cadmium/toxicity*
- PubMed
- 28259580 Full text @ Environ. Pollut.
Abstract
As an emerging contaminant, 1-H-benzotriazole (1H-BTR) has been detected in the engineered and natural aquatic environments, which usually coexists with heavy metals and causes combined pollution. In the present study, wild-type and transgenic zebrafish Danio rerio were used to explore the acute toxicity as well as the single and joint hepatotoxicity of cadmium (Cd) and 1H-BTR. Although the acute toxicity of 1H-BTR to zebrafish was low, increased expression of liver-specific fatty acid binding protein was observed in transgenic zebrafish when the embryos were exposed to 5.0 ?M of 1H-BTR for 30 days. Besides, co-exposure to 1H-BTR not only reduced the acute toxic effects induced by Cd, but also alleviated the Cd-induced liver atrophy in transgenic fish. Correspondingly, effects of combined exposure to 1H-BTR on the Cd-induced expressions of several signal pathway-related genes and superoxide dismutase and glutathione-s-transferase proteins were studied. Based on the determination of Cd bioaccumulation in fish and the complexing stability constant (?) of Cd-BTR complex in solution, the detoxification mechanism of co-existing 1H-BTR on Cd to the zebrafish was discussed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping