PUBLICATION
The use of fish models to study human neurological disorders
- Authors
- Matsui, H.
- ID
- ZDB-PUB-170222-21
- Date
- 2017
- Source
- Neuroscience research 120: 1-7 (Review)
- Registered Authors
- Matsui, Hideaki
- Keywords
- Fish, Neurological disorders, Neuroscience, Parkinson’s disease, Teleost
- MeSH Terms
-
- Animals
- Behavior, Animal
- Brain/physiopathology
- Disease Models, Animal*
- Fishes*
- Humans
- Nervous System Diseases*/physiopathology
- Neurons/physiology
- Oryzias
- Zebrafish
- PubMed
- 28215820 Full text @ Neurosci. Res.
Citation
Matsui, H. (2017) The use of fish models to study human neurological disorders. Neuroscience research. 120:1-7.
Abstract
Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseases and psychiatric disorders. This review summarizes the advantages and disadvantages of using fish for neuropsychiatric research using primarily our own studies as examples. We discuss how fish belong to a class of vertebrates, are feasible for imaging, and include diverse species with multiple research possibilities yet to be discovered.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping