PUBLICATION

miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants

Authors
Desvignes, T., Batzel, P., Berezikov, E., Eilbeck, K., Eppig, J.T., McAndrews, M.S., Singer, A., Postlethwait, J.H.
ID
ZDB-PUB-170214-99
Date
2015
Source
Trends in genetics : TIG   31: 613-26 (Review)
Registered Authors
Desvignes, Thomas, Eppig, Janan, Postlethwait, John H., Singer, Amy
Keywords
isomiR, loop-origin miRNAs, miRNA cluster, miRNA-seq, moR, noncoding RNA
MeSH Terms
  • Humans
  • DEAD-box RNA Helicases/genetics
  • DEAD-box RNA Helicases/metabolism
  • Animals
  • RNA, Small Interfering/genetics
  • RNA, Small Interfering/metabolism
  • MicroRNAs/classification*
  • MicroRNAs/genetics*
  • MicroRNAs/metabolism
  • Sequence Analysis, RNA
  • Zebrafish
  • RNA, Small Cytoplasmic/genetics
  • RNA, Small Cytoplasmic/metabolism
  • Ribonuclease III/genetics
  • Ribonuclease III/metabolism
  • Genetic Variation*
  • Transcriptome
  • Biosynthetic Pathways/genetics*
  • Terminology as Topic*
  • Mice
  • Gene Expression Regulation
PubMed
26453491 Full text @ Trends Genet.
Abstract
High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of miRNAs to encompass this diversity. We then review nomenclature guidelines for miRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations (i.e., isomiRs) in the analysis of small RNA sequencing experiments.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping