|ZFIN ID: ZDB-PUB-170214-188|
IBD. Fishing for missing heritability in IBD
|Source:||Nature reviews. Gastroenterology & hepatology 12: 318-20 (Review)|
|Registered Authors:||Pack, Michael|
|Keywords:||Experimental models of disease, Inflammatory bowel disease, Pathogenesis|
|PubMed:||25942704 Full text @ Nat Rev Gastroenterol Hepatol|
Pack, M. (2015) IBD. Fishing for missing heritability in IBD. Nature reviews. Gastroenterology & hepatology. 12:318-20.
ABSTRACTA genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing evidence is presented that alterations in the epigenetic regulation of TNF might contribute to the "missing heritability" of IBD.
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