ZFIN ID: ZDB-PUB-170214-188
IBD. Fishing for missing heritability in IBD
Pack, M.
Date: 2015
Source: Nature reviews. Gastroenterology & hepatology   12: 318-20 (Review)
Registered Authors: Pack, Michael
Keywords: Experimental models of disease, Inflammatory bowel disease, Pathogenesis
MeSH Terms:
  • Animals
  • DNA Methylation*
  • Epigenesis, Genetic/physiology*
  • Inflammatory Bowel Diseases/metabolism*
  • Intestinal Mucosa/embryology*
  • Zebrafish/embryology*
PubMed: 25942704 Full text @ Nat Rev Gastroenterol Hepatol
ABSTRACT
A genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing evidence is presented that alterations in the epigenetic regulation of TNF might contribute to the "missing heritability" of IBD.
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