PUBLICATION
Volume Changes During Active Shape Fluctuations in Cells
- Authors
- Taloni, A., Kardash, E., Salman, O.U., Truskinovsky, L., Zapperi, S., La Porta, C.A.
- ID
- ZDB-PUB-170214-173
- Date
- 2015
- Source
- Physical review letters 114: 208101 (Journal)
- Registered Authors
- Kardash, Elena
- Keywords
- none
- MeSH Terms
-
- Osmotic Pressure
- Aquaporin 1/metabolism
- rho-Associated Kinases/metabolism
- Algorithms
- Animals
- Aquaporin 3/metabolism
- Models, Biological*
- Germ Cells/cytology*
- Germ Cells/metabolism*
- Zebrafish
- Cell Shape/physiology*
- Water/chemistry
- Microscopy, Confocal
- Cell Membrane/metabolism
- Computer Simulation
- PubMed
- 26047252 Full text @ Phys. Rev. Lett.
Citation
Taloni, A., Kardash, E., Salman, O.U., Truskinovsky, L., Zapperi, S., La Porta, C.A. (2015) Volume Changes During Active Shape Fluctuations in Cells. Physical review letters. 114:208101.
Abstract
Cells modify their volume in response to changes in osmotic pressure but it is usually assumed that other active shape variations do not involve significant volume fluctuations. Here we report experiments demonstrating that water transport in and out of the cell is needed for the formation of blebs, commonly observed protrusions in the plasma membrane driven by cortex contraction. We develop and simulate a model of fluid-mediated membrane-cortex deformations and show that a permeable membrane is necessary for bleb formation which is otherwise impaired. Taken together, our experimental and theoretical results emphasize the subtle balance between hydrodynamics and elasticity in actively driven cell morphological changes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping