PUBLICATION
Zebrafish screens for new colitis treatments - a bottom-up approach
- Authors
- Lee, J.A., Renshaw, S.A.
- ID
- ZDB-PUB-170209-16
- Date
- 2017
- Source
- The FEBS journal 284: 399-401 (Review)
- Registered Authors
- Renshaw, Steve A.
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Anti-Inflammatory Agents/pharmacology*
- Colitis, Ulcerative/chemically induced
- Colitis, Ulcerative/drug therapy*
- Colitis, Ulcerative/immunology
- Colitis, Ulcerative/pathology
- Crohn Disease/chemically induced
- Crohn Disease/drug therapy*
- Crohn Disease/immunology
- Crohn Disease/pathology
- Dextran Sulfate
- Disease Models, Animal
- Dysbiosis/chemically induced
- Dysbiosis/drug therapy*
- Dysbiosis/immunology
- Dysbiosis/pathology
- High-Throughput Screening Assays*
- Humans
- Immunologic Factors/pharmacology*
- Intestines/drug effects
- Intestines/immunology
- Intestines/pathology
- Neutrophils/drug effects
- Neutrophils/immunology
- Neutrophils/pathology
- Trinitrobenzenesulfonic Acid
- Zebrafish
- PubMed
- 28168859 Full text @ FEBS J.
Citation
Lee, J.A., Renshaw, S.A. (2017) Zebrafish screens for new colitis treatments - a bottom-up approach. The FEBS journal. 284:399-401.
Abstract
Many factors interact in the development and progression of inflammatory bowel disease. This complexity demands a combination of methods to disentangle the pathology of this disease. As reported by Oehlers et al. in this issue, the zebrafish drug screen is one simple approach that could enable the elucidation of the pathways involved in IBD and ultimately the discovery of new therapeutics.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping