PUBLICATION
Chemical screening in zebrafish for novel biological and therapeutic discovery
- Authors
- Wiley, D.S., Redfield, S.E., Zon, L.I.
- ID
- ZDB-PUB-170129-5
- Date
- 2017
- Source
- Methods in cell biology 138: 651-679 (Chapter)
- Registered Authors
- Zon, Leonard I.
- Keywords
- Chemical, Chemoinformatic, Hit, Libraries, Phenotype, Screen, Zebrafish
- MeSH Terms
-
- Animals
- Drug Discovery/methods*
- Drug Evaluation, Preclinical/methods*
- Embryo, Nonmammalian/drug effects
- High-Throughput Screening Assays/methods*
- Humans
- Small Molecule Libraries/pharmacology
- Zebrafish/genetics
- Zebrafish/growth & development*
- PubMed
- 28129862 Full text @ Meth. Cell. Biol.
Citation
Wiley, D.S., Redfield, S.E., Zon, L.I. (2017) Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods in cell biology. 138:651-679.
Abstract
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping