PUBLICATION

Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis

Authors
Frame, J.M., Lim, S.E., North, T.E.
ID
ZDB-PUB-170129-24
Date
2017
Source
Methods in cell biology   138: 165-192 (Chapter)
Registered Authors
North, Trista
Keywords
Embryo, Hematopoiesis, Hematopoietic stem cell (HSC), Hemogenic endothelium, Zebrafish
MeSH Terms
  • Animals
  • Embryonic Development/genetics*
  • Hematopoiesis/genetics*
  • Hematopoietic Stem Cells/cytology*
  • Zebrafish/genetics
  • Zebrafish/growth & development*
PubMed
28129843 Full text @ Meth. Cell. Biol.
Abstract
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. Since the genetic programs regulating HSC development are highly conserved between vertebrate species, experimental studies in zebrafish have not only complemented observations reported in mammals but have also yielded important discoveries that continue to influence our understanding of HSC biology and homeostasis. Here, we summarize findings that have established zebrafish as an important conserved model for the study of hematopoiesis, and describe methods that can be utilized for future investigations of zebrafish HSC biology.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes