Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis
- Frame, J.M., Lim, S.E., North, T.E.
- Methods in cell biology 138: 165-192 (Chapter)
- Registered Authors
- North, Trista
- Embryo, Hematopoiesis, Hematopoietic stem cell (HSC), Hemogenic endothelium, Zebrafish
- MeSH Terms
- Embryonic Development/genetics*
- Hematopoietic Stem Cells/cytology*
- Zebrafish/growth & development*
- 28129843 Full text @ Meth. Cell. Biol.
Frame, J.M., Lim, S.E., North, T.E. (2017) Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis. Methods in cell biology. 138:165-192.
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. Since the genetic programs regulating HSC development are highly conserved between vertebrate species, experimental studies in zebrafish have not only complemented observations reported in mammals but have also yielded important discoveries that continue to influence our understanding of HSC biology and homeostasis. Here, we summarize findings that have established zebrafish as an important conserved model for the study of hematopoiesis, and describe methods that can be utilized for future investigations of zebrafish HSC biology.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes