|ZFIN ID: ZDB-PUB-170129-11|
Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling
Kim, H.R., Greenald, D., Vettori, A., Markham, E., Santhakumar, K., Argenton, F., van Eeden, F.
|Source:||Methods in cell biology 138: 497-523 (Chapter)|
|Registered Authors:||Argenton, Francesco, Santhakumar, Kiran, van Eeden, Freek, Vettori, Andrea|
|Keywords:||Angiogenesis, Cancer, Circadian clock, HIF reporter, Hypoxia, Hypoxia responsive element, Hypoxia-inducible factor, Metabolism, Oxygen, Polycythemia, Prolyl hydroxylase, Zebrafish, von Hippel Lindau|
|PubMed:||28129856 Full text @ Meth. Cell. Biol.|
Kim, H.R., Greenald, D., Vettori, A., Markham, E., Santhakumar, K., Argenton, F., van Eeden, F. (2017) Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling. Methods in cell biology. 138:497-523.
ABSTRACTOxygen is a central molecule in the development of multicellular life, allowing efficient energy generation. Inadequate oxygen supply requires rapid adaptations to prevent cellular damage and the hypoxia-inducible factor (HIF) pathway plays a central role in this adaptation. Numerous diseases and disease processes are influenced by hypoxia and the HIF pathway. One component, von Hippel Lindau (VHL), is a well-known tumor suppressor, which acts at least in part via regulating HIF signaling. The zebrafish has become a central vertebrate model organism in which developmental and disease processes can be studied. In this review, we have tried to bring together knowledge on the HIF/hypoxic signaling pathway in zebrafish, including what is known on VHL functions.
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