PUBLICATION
Dietary sodium propionate affects mucosal immune parameters, growth and appetite related genes expression: insights from zebrafish model
- Authors
- Hossein Hoseinifar, S., Safari, R., Dadar, M.
- ID
- ZDB-PUB-161114-5
- Date
- 2017
- Source
- General and comparative endocrinology 243: 78-83 (Journal)
- Registered Authors
- Keywords
- Appetite, Growth hormone, Mucosal Immunity, Myostatin, Physiological response, Short -chain fatty acids
- MeSH Terms
-
- Animal Feed
- Animals
- Appetite/genetics*
- Gene Expression Regulation/drug effects*
- Immunity, Mucosal/genetics*
- Propionates/pharmacology*
- Sodium, Dietary/pharmacology*
- Zebrafish/genetics*
- Zebrafish/growth & development
- Zebrafish/immunology
- Zebrafish Proteins/genetics*
- PubMed
- 27838381 Full text @ Gen. Comp. Endocrinol.
Citation
Hossein Hoseinifar, S., Safari, R., Dadar, M. (2017) Dietary sodium propionate affects mucosal immune parameters, growth and appetite related genes expression: insights from zebrafish model. General and comparative endocrinology. 243:78-83.
Abstract
Propionate is a short-chain fatty acid (SCFA) that improves physiological and pathophysiological proprieties. However, there is limited information available about the effects of SCFA on mucosal immune parameters as well as growth and appetite related genes expression. The aim of the present study was to evaluate the effect of sodium propionate (SP) intake on the mucosal immune parameters, growth and appetite related genes expression using zebrafish (Danio rerio) as model organism. Zebrafish fed control or diet supplemented with different levels (0.5, 1 and 2%) of SP for 8 weeks. At the end of feeding trial, the expression of the key genes related to growth and appetite (GH, IGF1, MYSTN and Ghrl) was evaluated. Also, mucosal immune parameters (Total Ig, lysozyme and protease activity) were studied in skin mucus of zebrafish. The results showed that dietary administration of SP significantly (P < 0.05) up-regulated the expression of GH, IGF1 and down-regulated MYSTN gene. Also, feeding zebrafish with SP supplemented diet significantly increased appetite related gene expression (P < 0.05) with a more pronounced effect in higher inclusion levels. Compared with control group, the expression of appetite related gene (Ghrl) was remarkably (P < 0.05) higher in SP fed zebrafish. Also, elevated mucosal immune parameters was observed in zebrafish fed SP supplemented diet. The present results revealed beneficial effects of dietary SP on mucosal immune response and growth and appetite related genes expression. These results also highlighted the potential use of SP as additive in human diets.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping