PUBLICATION
Spontaneous alternation behavior in larval zebrafish
- Authors
- Bögli, S.Y., Huang, M.Y.
- ID
- ZDB-PUB-161105-11
- Date
- 2017
- Source
- The Journal of experimental biology 220(Pt 2): 171-173 (Journal)
- Registered Authors
- Bögli, Stefan, Huang, Melody Ying-Yu
- Keywords
- Zebrafish, SAB, Maze, Memory, Cognition
- MeSH Terms
-
- Animals
- Cognition
- Maze Learning*
- Memory*
- Zebrafish/physiology*
- PubMed
- 27811295 Full text @ J. Exp. Biol.
Citation
Bögli, S.Y., Huang, M.Y. (2017) Spontaneous alternation behavior in larval zebrafish. The Journal of experimental biology. 220(Pt 2):171-173.
Abstract
Spontaneous alternation behavior (SAB) describes the tendency of animals to alternate their turn direction in consecutive turns. SAB, dissimilar from other mnestic tasks, does not require any prior training or reinforcement. Due to its close correlation to the development and function of hippocampus in mice, it is thought to reflect a type of memory. Adult zebrafish possess a hippocampus-like structure utilizing the same neurotransmitters as in human brains, and have thus been used to study memory. In the current study we established SAB in zebrafish larvae at 6 days post fertilization using a custom made forced-turn maze with a rate of 57%. Our demonstration of SAB's presence in larval zebrafish at a very early developmental stage not only provides evidence for early cognition in this species but suggests its future use as a high-throughput model for mnestic studies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping