PUBLICATION

Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

Authors
Liu, J., Zhu, Y., Luo, G.Z., Wang, X., Yue, Y., Wang, X., Zong, X., Chen, K., Yin, H., Fu, Y., Han, D., Wang, Y., Chen, D., He, C.
ID
ZDB-PUB-161008-11
Date
2016
Source
Nature communications   7: 13052 (Journal)
Registered Authors
Chen, Kai, He, Chuan
Keywords
Chemical modification, DNA methylation, Embryogenesis
Datasets
GEO:GSE76740
MeSH Terms
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Genome
  • Repetitive Sequences, Nucleic Acid/genetics
  • DNA Methylation/genetics*
  • Animals
  • Deoxyadenosines/chemistry*
  • Embryonic Development/genetics*
  • DNA/chemistry*
  • Swine/embryology*
  • Swine/genetics
(all 11)
PubMed
27713410 Full text @ Nat. Commun.
Abstract
DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.
Genes / Markers
Figures
Figure Gallery (2 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
No data available
Fish
Fish
TU
1 - 1 of 1
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Antibodies
Name Type Antigen Genes Isotypes Host Organism
Ab1-m6Apolyclonal
    		IgGRabbit
    Ab2-m6Apolyclonal
      		Rabbit
      1 - 2 of 2
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      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available
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      Citation
      Liu, J., Zhu, Y., Luo, G.Z., Wang, X., Yue, Y., Wang, X., Zong, X., Chen, K., Yin, H., Fu, Y., Han, D., Wang, Y., Chen, D., He, C. (2016) Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nature communications. 7:13052.