PUBLICATION

Ritanserin-sensitive receptors modulate the prosocial and the anxiolytic effect of MDMA derivatives, DOB and PMA, in zebrafish

Authors
Ponzoni, L., Sala, M., Braida, D.
ID
ZDB-PUB-160811-11
Date
2016
Source
Behavioural brain research   314: 181-9 (Journal)
Registered Authors
Keywords
Zebrafish, hallucinogens, light-dark, novel tank, social preference
MeSH Terms
  • Ritanserin/pharmacology*
  • Zebrafish
  • Animals
  • Behavior, Animal/drug effects*
  • Anti-Anxiety Agents/pharmacology*
  • Anxiety/drug therapy
  • Anxiety/psychology
  • Hallucinogens/pharmacology
  • Motor Activity/drug effects
  • N-Methyl-3,4-methylenedioxyamphetamine/pharmacology*
(all 10)
PubMed
27506653 Full text @ Behav. Brain Res.
Abstract
Little is known about the pharmacological effects of amphetamine derivatives. In the present study, the effect on social preference and anxiety-like behavior of 2,5-dimetoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine (PMA), in comparison with 3,4 methylenedioxymethamphetamine (MDMA) was investigated in zebrafish, an emerging model to study emotional behavior in an inexpensive and quick manner. DOB (0.05-2mg/kg), PMA (0.0005-2mg/kg) or MDMA (0.25-20mg/kg), given i.m. to adult zebrafish, progressively increased the time spent in the proximity of nacre fish picture in a social preference test. However, high doses were ineffective. Similarly, in the novel tank diving and light-dark tests the compounds elicited a progressive anxiolytic effect in terms of time spent in the upper half of the tank and in the light compartment, respectively. All the above effects were interpolated by symmetrical parabolas. The 5-HT2A/C antagonist ritanserin (0.025-2.5mg/kg) in association with the maximal effective dose of MDMA, DOB and PMA blocked both the social and anxiolytic effect. Taken together these findings demonstrate for the first time the prosocial and anxiolytic properties of DOB and PMA and focus on the mechanisms of their action through the serotonergic-like system suggesting a potential clinical application.
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Citation
Ponzoni, L., Sala, M., Braida, D. (2016) Ritanserin-sensitive receptors modulate the prosocial and the anxiolytic effect of MDMA derivatives, DOB and PMA, in zebrafish. Behavioural brain research. 314:181-9.