PUBLICATION
Myocardial plasticity: cardiac development, regeneration and disease
- Authors
- Bloomekatz, J., Galvez-Santisteban, M., Chi, N.C.
- ID
- ZDB-PUB-160809-9
- Date
- 2016
- Source
- Current opinion in genetics & development 40: 120-130 (Review)
- Registered Authors
- Bloomekatz, Joshua, Chi, Neil C.
- Keywords
- none
- MeSH Terms
-
- Ambystoma mexicanum/genetics
- Ambystoma mexicanum/growth & development
- Animals
- Cell Dedifferentiation/genetics*
- Cell Proliferation/genetics
- Heart/growth & development*
- Humans
- Myocytes, Cardiac/physiology*
- Regeneration/genetics*
- Zebrafish/genetics
- Zebrafish/growth & development
- PubMed
- 27498024 Full text @ Curr. Opin. Genet. Dev.
Citation
Bloomekatz, J., Galvez-Santisteban, M., Chi, N.C. (2016) Myocardial plasticity: cardiac development, regeneration and disease. Current opinion in genetics & development. 40:120-130.
Abstract
The adult mammalian heart is unable to recover from myocardial cell loss due to cardiac ischemia and infarction because terminally differentiated cardiomyocytes proliferate at a low rate. However, cardiomyocytes in other vertebrate animal models such as zebrafish, axolotls, newts and mammalian mouse neonates are capable of de-differentiating in order to promote cardiomyocyte proliferation and subsequent cardiac regeneration after injury. Although de-differentiation may occur in adult mammalian cardiomyocytes, it is typically associated with diseased hearts and pathologic remodeling rather than repair and regeneration. Here, we review recent studies of cardiac development, regeneration and disease that highlight how changes in myocardial identity (plasticity) is regulated and impacts adaptive and maladaptive cardiac responses.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping