Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
- Rajan, V., Dellaire, G., Berman, J.N.
- Methods in molecular biology (Clifton, N.J.) 1451: 171-89 (Chapter)
- Registered Authors
- Berman, Jason, Rajan, Vinothkumar
- Meganuclease, Patient-derived xenograft, Transgenesis, Xenograft
- MeSH Terms
- Animals, Genetically Modified/genetics
- Animals, Genetically Modified/metabolism*
- Animals, Genetically Modified/physiology*
- Disease Models, Animal
- 27464808 Full text @ Meth. Mol. Biol.
Rajan, V., Dellaire, G., Berman, J.N. (2016) Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models. Methods in molecular biology (Clifton, N.J.). 1451:171-89.
The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes