PUBLICATION

Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models

Authors
Rajan, V., Dellaire, G., Berman, J.N.
ID
ZDB-PUB-160729-18
Date
2016
Source
Methods in molecular biology (Clifton, N.J.)   1451: 171-89 (Chapter)
Registered Authors
Berman, Jason, Rajan, Vinothkumar
Keywords
Meganuclease, Patient-derived xenograft, Transgenesis, Xenograft
MeSH Terms
  • Animals
  • Animals, Genetically Modified/genetics
  • Animals, Genetically Modified/metabolism*
  • Animals, Genetically Modified/physiology*
  • Carcinogenesis/metabolism
  • Carcinogenesis/pathology
  • Disease Models, Animal
  • Heterografts/metabolism
  • Heterografts/pathology
  • Humans
  • Leukemia/metabolism*
  • Leukemia/pathology*
  • Mutation/genetics
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish/physiology*
PubMed
27464808 Full text @ Meth. Mol. Biol.
Abstract
The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes