PUBLICATION

The Regenerative Potential of the Vertebrate Retina: Lessons from the Zebrafish

Authors
Ng, J., Currie, P., Jusuf, P. R.
ID
ZDB-PUB-160726-1
Date
2014
Source
Regenerative Biology of the Eye : 49-82 (Chapter)
Registered Authors
Currie, Peter D., Jusuf, Patricia, Ng, Jeremy
Keywords
none
MeSH Terms
none
PubMed
none Full text @ Regenerative Biology of the Eye
Abstract
The regenerative potential, forward/reverse genetic capabilities and technical advantages of the zebrafish make it an ideal model for studying signals and mechanisms that drive retinal regeneration. Here, we describe the different cellular sources of regeneration in zebrafish, with a particular emphasis on Müller glia cells, as well as the individual signalling pathways that specifically co-ordinate the different phases of regeneration. Because the same cells are also generated developmentally, a comparison between developmental and regenerative processes is of particular benefit to identify the extent to which we can drive developmental mechanisms to improve adult regenerative responses. Given the recent identification of many conserved signalling pathways using zebrafish developmental studies, we can now use this model system to assess their involvement during regeneration. Finally, identifying similarities and differences between zebrafish and amniotic vertebrates allows us to distinguish between the intrinsic capacity and extrinsic signals that can improve regeneration. Thus, we aim to highlight data obtained from the zebrafish vertebrate model and how this information can and has contributed to and directed mammalian research.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping