PUBLICATION
Epigenetic regulation of hematopoietic stem cell development
- Authors
- Li, C., Evans, T., Goll, M.G.
- ID
- ZDB-PUB-160725-14
- Date
- 2016
- Source
- Methods in cell biology 135: 431-48 (Chapter)
- Registered Authors
- Evans, Todd, Goll, Mary
- Keywords
- Acetylation, DNA methylation, Embryogenesis, Genetics, Hemogenic endothelium, Hydroxymethylcytosine, TET genes, Zebrafish
- MeSH Terms
-
- Animals
- Cell Lineage/genetics
- Epigenesis, Genetic*
- Epigenomics/methods*
- Genetic Engineering/methods*
- Hematopoietic Stem Cells*
- Signal Transduction/genetics
- Zebrafish/genetics
- PubMed
- 27443939 Full text @ Meth. Cell. Biol.
Citation
Li, C., Evans, T., Goll, M.G. (2016) Epigenetic regulation of hematopoietic stem cell development. Methods in cell biology. 135:431-48.
Abstract
Hematopoietic stem cells (HSCs) are multipotent self-renewing precursors with the capacity to differentiate into all adult blood cell lineages. HSC development is a highly orchestrated process regulated by multiple transcription factors and signaling pathways. Emerging evidence suggests that epigenetic regulation is an additional essential component of HSC development. Powerful genetic and imaging approaches, combined with conservation of mammalian programs, have made zebrafish a prominent model for the study of HSC production. This chapter summarizes approaches that have been used to identify epigenetic regulators of HSC development in zebrafish and highlights additional strategies that are likely to facilitate progress in this promising field.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping