PUBLICATION

Function and Regulation of the Wilms' Tumor Suppressor 1 (WT1) Gene in Fish

Authors
Perner, B., Bates, T.J., Naumann, U., Englert, C.
ID
ZDB-PUB-160716-10
Date
2016
Source
Methods in molecular biology (Clifton, N.J.)   1467: 119-28 (Chapter)
Registered Authors
Englert, Christoph, Perner, Birgit
Keywords
Glomerulus, Kidney, Mesonephros, Podocyte, Pronephros, Regeneration, Zebrafish
MeSH Terms
  • Animals
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation, Developmental
  • Heart/growth & development
  • Kidney/growth & development
  • Kidney/metabolism
  • Myocardium/metabolism
  • Pronephros/growth & development
  • Pronephros/metabolism
  • WT1 Proteins/genetics*
  • WT1 Proteins/metabolism*
  • Zebrafish/embryology*
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism*
PubMed
27417964 Full text @ Meth. Mol. Biol.
Abstract
The Wilms' tumor suppressor gene Wt1 is highly conserved among vertebrates. In contrast to mammals, most fish species possess two wt1 paralogs that have been named wt1a and wt1b. Concerning wt1 in fish, most work so far has been done using zebrafish, focusing on the embryonic kidney, the pronephros. In this chapter we will describe the structure and development of the pronephros as well as the role that the wt1 genes play in the embryonic zebrafish kidney. We also discuss Wt1 target genes and describe the potential function of the Wt1 proteins in the adult kidney. Finally we will summarize data on the role of Wt1 outside of the kidney.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping