PUBLICATION
Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish
- Authors
- Jiang, C., Wang, P., Li, M., Liu, S., Zhang, S.
- ID
- ZDB-PUB-160706-8
- Date
- 2016
- Source
- Developmental and comparative immunology 65: 107-13 (Journal)
- Registered Authors
- Keywords
- Danio rerio, Glucan, Immunostimulator, Maternal immunity, Zebrafish
- MeSH Terms
-
- Animals
- Anti-Infective Agents/metabolism
- Cells, Cultured
- Complement C3/immunology
- Complement C3/metabolism*
- Complement Factor B/immunology
- Complement Factor B/metabolism*
- Diet
- Dietary Carbohydrates/administration & dosage*
- Female
- Fetal Development*
- Immunity, Maternally-Acquired
- Immunization
- Pregnancy
- Zebrafish/immunology*
- Zygote/metabolism*
- beta-Glucans/administration & dosage*
- PubMed
- 27375187 Full text @ Dev. Comp. Immunol.
Citation
Jiang, C., Wang, P., Li, M., Liu, S., Zhang, S. (2016) Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish. Developmental and comparative immunology. 65:107-13.
Abstract
β-glucan has been shown to increase non-specific immunity and resistance against infections or pathogenic bacteria in several fish species, but no information is available regarding its trans-generational effects to date. Here we clearly demonstrated that β-glucan enhanced the contents of immune-relevant molecules C3 and Bf in eggs of zebrafish, and the embryos derived from β-1,3 glucan-treated zebrafish were more resistant to bacterial challenge than control embryos. Moreover, the transferred C3 and Bf were directly associated with the antimicrobial defense of early embryos. In addition, feeding female zebrafish with β-glucan had little detrimental effects on the number of spawned eggs and their embryonic development. Collectively, these data show for the first time that β-glucan can be safely used to promote the non-specific immunity in offspring of fishes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping